The Nodal Standard Uptake Value (SUV) as a Prognostic Factor in Head and Neck Squamous Cell Cancer

Background/Aims: The aim of present study is to evaluate the predictive and prognostic role of high [18F]fluoro-D-glucose (FDG) uptake of primary tumor and nodal metastasis in squamous cell carcinoma of head andneck (HNSCC). Methodology and Patients: Between February 2006 and July 2010, we retrospectively evaluated64 patients with primary HNSCC in an institutional imaging trial. All patients who underwent evaluationpretreatment FDG-positron emission tomography/ computarized tomography (FDG-PET/CT) imaging and 33(51%) had pre- and after treatment FDG-PET/CT imaging. All treatments were performed with curative intent.Abnormal FDG uptakes were analyzed using maximum standardized uptake values (SUVm). The disease-freesurvival (DFS) and overall survival (OS) were evaluated with several prognostic factors such as pre-treatmentSUVm and %change in SUVm.
Results: Tumor sites are nasopharynx (n= 29, 45.3%), larynx (n= 16, 25%),oropharynx (n= 13, 20.4%) and hypopharynx (n= 6, 9.4%). Median age was 58 (range: 16-87) and most patients(84.4%) had stage III/IV lesions. Objective response rate was 78.2 %. The median primary tumor SUVm was 13.4(range, 4.8–33.1), median nodal SUVm was 4.45 (range, 0–25.6) and median % change in SUVm was 74.1(range,-61-100). On multivariate analysis, nodal SUVm and surgery remained significant predictors of DFS. There wasno statistical significance found between survival and other factors.
Conclusions: We have found that whilenodal SUVm is prognostic for DFS, primary tumor SUVm and % change in SUVm are not.