Incidence Trends in Invasive Uterine Cervix Cancer and Carcinoma in Situ in Incheon, South Korea

Introduction: This study examined trends of invasive and carcinoma in situ(CIS) in terms of the incidence and mortality of uterine cervix cancer in Incheon over a twelve year period.
Methods: Uterine cervical cancer data were retrieved from the Incheon Cancer Registry(ICR) and Korea Central Cancer Registry(KCCR) from 1997 to 2008. The time trend in age-standardized incidence rates (ASR) of invasive uterine cervix cancer and CIS were calculated and compared with the nation-wide cancer registry data for each year. Mortality/incidence (M/I) ratios according to age and the incidence of pathological subtype in Incheon each year were also examined, along with an international comparison.
Results: A total of 3,096 cases of invasive cervical cancer and 2,079 cases of carcinoma in situ were analyzed from 1997 to 2008. The time trend incidence of the total ASR in uterine cervical cancer decreased from 25.7 in 1997 to 13.4 in 2008, but incidence of CIS increased from 7.6 to 15.8 in same period. In invasive cancers, the age-specific incidence rates were highest in those in their sixties and patients in their forties showed highest incidence of CIS. The mortality rate in ICR was 3.7 from 1998 to 2002. Compared to the other countries which have high risk factors for cervix cancer, the peak incidence zone was different in Incheon.
Conclusion: The ICR showed a decrease in the incidence of invasive cervical cancer that was similar to the nation-wide data. An early increase zone is a characteristic pattern in the age specific incidence curve. Early screening and a vaccination program should be activated for prevention of young age cervical cancer.