Dietary flavonoids have attracted attention as chemopreventive agents. Chalcones are abundantly present in nature starting from ferns to higher plants. Chemically 1,3-diphenyl-2-propen-1-ones, these are often cytotoxic in vitro. The cellular defense system (including glutathione, glutathione-related enzymes, and antioxidant and redox enzymes) plays a crucial role in cell survival and growth in aerobic organisms. In the present study, we aimed to evaluate the modulatory effect of trans-chalcone on protection from oxidative stress caused by hydrogen peroxide (H2O2) in hepatocellular carcinoma (HepG2) cells. Cell growth was evaluated by the 3-(4,5-dimethyl thiazol-2-yl)-2,5-diphenyl tetrazolium bromide (MTT) assay. Sub-toxic concentrations of compound (20uM) increased cell survival and a decreased lipid peroxidation. The drug also decreased the H2O2 induction of glutathione related enzymes. Our results support the efficacy of trans-chalcone in offering protection against oxidative stress.
(2011). Cytoprotective Activity of a Trans-chalcone Against Hydrogen Peroxide Induced Toxicity in Hepatocellular Carcinoma (HepG2) Cells. Asian Pacific Journal of Cancer Prevention, 12(10), 2513-2516.
MLA
. "Cytoprotective Activity of a Trans-chalcone Against Hydrogen Peroxide Induced Toxicity in Hepatocellular Carcinoma (HepG2) Cells". Asian Pacific Journal of Cancer Prevention, 12, 10, 2011, 2513-2516.
HARVARD
(2011). 'Cytoprotective Activity of a Trans-chalcone Against Hydrogen Peroxide Induced Toxicity in Hepatocellular Carcinoma (HepG2) Cells', Asian Pacific Journal of Cancer Prevention, 12(10), pp. 2513-2516.
VANCOUVER
Cytoprotective Activity of a Trans-chalcone Against Hydrogen Peroxide Induced Toxicity in Hepatocellular Carcinoma (HepG2) Cells. Asian Pacific Journal of Cancer Prevention, 2011; 12(10): 2513-2516.