Lack of Association Between the 8-oxoguanine DNA Glycosylase Gene Ser326Cys Polymorphism and Gastric Cancer: Evidence from a Meta-Analysis


Objective: To evaluate the association of 8-oxoguanine DNA glycosylase gene (OGG1) Ser326Cys polymorphism with gastric cancer via a comprehensive meta-analysis.
Methods: A total of 12 publications were identified before January 20, 2011 including 1,390 cases and 3,299 controls. A random-effects model was applied irrespective of between-study heterogeneity. Data and study quality were assessed in duplicate.
Results: No significant association was found for either allele or genotype with gastric cancer (odds ratio [OR]=0.96; 95% confidence interval [95% CI]: 0.82–1.13; P=0.66), and this was also the case after combining 326Ser/Cys and 326Ser/Ser genotypes together (OR=0.87; 95% CI: 0.63–1.20; P=0.40), or 326Cys/Cys and 326Ser/Cys together (OR=1.03; 95% CI: 0.87–1.22; P=0.72). Subgroup analysis by ethnicity indicated that comparison of allele 326Ser versus 326Cys generated a weakly and non-significantl protective effect on gastric cancer in Asians (OR=0.90; 95% CI: 0.75–1.09; P=0.29) and Turks (OR=0.65; 95% CI: 0.37–1.14; P=0.13), but a non-significant risk effect in Europeans (OR=1.10; 95% CI: 0.78–1.54; P=0.60) and Brazilians (OR=1.13; 95% CI: 0.81–1.58; P=0.48). No publication bias was observed.
Conclusions: Our results collectively suggest that the OGG1 Ser326Cys polymorphism might not be a potential candidate risk factor for the development of gastric cancer.