Triosephosphate isomerase (TPI), a glycolytic enzyme, functions in catalyzing the interconversion of glyceraldehyde-3-phosphate and dihydroxyacetone phosphate and is generally upregulated in tumours. However, there are data suggesting loss in lymphomas. To determine its effects in chicken embryonal fibroblasts (CEF) a plasmid was constructed to allow transfection. Upon culture in a suitable medium, cells transfected with the TPI demonstrated upregulation and were significantly more susceptible to apoptosis compared to controls with decreased proliferation. These finding therefore render a novel mechanism by which CEF can be triggered to undergo death by upregulation of TPI.
(2011). Overexpression of Triosephosphate Isomerase Inhibits Proliferation of Chicken Embryonal Fibroblast Cells. Asian Pacific Journal of Cancer Prevention, 12(12), 3479-3482.
MLA
. "Overexpression of Triosephosphate Isomerase Inhibits Proliferation of Chicken Embryonal Fibroblast Cells". Asian Pacific Journal of Cancer Prevention, 12, 12, 2011, 3479-3482.
HARVARD
(2011). 'Overexpression of Triosephosphate Isomerase Inhibits Proliferation of Chicken Embryonal Fibroblast Cells', Asian Pacific Journal of Cancer Prevention, 12(12), pp. 3479-3482.
VANCOUVER
Overexpression of Triosephosphate Isomerase Inhibits Proliferation of Chicken Embryonal Fibroblast Cells. Asian Pacific Journal of Cancer Prevention, 2011; 12(12): 3479-3482.
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