Factors Influencing Axillary Lymph Node Metastasis in Invasive Breast Cancer

Purpose: To explore the relationship between auxiliary lymph node metastasis and clinical features, andto identify the factors that affect metastasis occurrence.
Methods: A total of 164 cases of primary breastcancer were selected to investigate features such as age, concomitant chronic disease and pathologic diagnosis.Immunohistochemistry was used to detect the expression of the estrogen receptor (ER) and CerbB-2. Logisticregression was employed to analyze the factors that affect the incidence of lymph node metastases.
Results: Theincidence of lymph node metastases was 46.3% among elderly patients with breast cancer. Based on logisticregression, chronic disease, scale of tumor, age, and ER expression affected the occurrence of lymph nodemetastases; the ORs were 3.05, 2.18, 0.34, and 3.83, respectively. Between different pathologic diagnoses andthe risk factors, the OR scores were 12.7 and 8.02, respectively, for aggressive ductal carcinoma and aggressivelobular carcinoma auxiliary lymph node metastases.
Conclusion: The incidence of lymph node metastases isaffected by chronic disease, scale of tumor, age, ER expression and pathologic diagnosis.