Objective: The objective of present study is to investigate the determinants of smoking behaviour among adultsin Malaysia. Method: Findings of the Third National Health and Morbidity Survey (NHMS-3) by the Ministryof Health, Malaysia, were used. The sample consisted of 34,539 observations. A logistic regression model wasthus applied to estimate the probability to participate in smoking. Results: Age, income, gender, marital status,ethnicity, employment status, residential area, education, lifestyle and health status were statistically significantin affecting the likelihood of smoking. Specifically, youngsters, low income earners, males, unmarried individuals,Malays, employed individuals, rural residents and primary educated individuals were more likely to smoke. Conclusion: In conclusion, socio-demographic, lifestyle and health factors have significant impacts on smokingparticipation in Malaysia. Based on these empirical findings, several policy implications are suggested.