Aim: To clarify any association between the hOGG1 Ser326Cys polymorphism and susceptibility to gastriccancer.
Methods: A meta-analysis based on 11 eligible case-control studies involving 5,107 subjects was carriedout to summarize the data on the association between hOGG1 Ser326Cys polymorphism and gastric cancer risk.
Results: No association was found between hOGG1 Ser326Cys polymorphism and gastric cancer risk (dominantmodel: OR = 0.95, 95% CI: 0.83-1.09, p = 0.486, ph (p values for heterogeneity) = 0.419; additive model: OR =1.02, 95% CI: 0.81-1.30, p = 0.850, ph = 0.181; recessive model: OR = 1.09, 95% CI: 0.80-1.48, p = 0.586, ph =0.053). Subgroup analysis based on ethnicity (Asian and Caucasian) and smoking status (ever smoker and neversmoker) did did notpresent any significant association. Sensitivity analysis did not perturb the results.
Conclusions:This study strongly suggested there might be no association between the hOGG1 Ser326Cys polymorphism andgastric cancer risk. However, larger scale studies are needed for confirmation.