Values of Three Different Preoperative Regimens in Comprehensive Treatment For Young Patients with Stage Ib2 Cervical Cancer

Objective: To compare the clinical efficacy of concurrent chemoradiotherapy, neoadjuvant chemotherapy,and intracavity brachytherapy in comprehensive treatment for young patients with stage Ib2 cervical cancer.
Methods: One hundred and twelve young patients with stage Ib2 cervical cancer were enrolled retrospectively inour hospital from January 2003 to June 2005. They were categorized into three groups according to preoperativeregimens, including the concurrent chemoradiotherapy group (Group 1, n=38), the neoadjuvant chemotherapy(Group 2, n=49), and the intracavity brachytherapy group (Group 3, n=25). Radical hysterectomy was performedfollowing these regimens. Chemotherapy and radiotherapy were given according to pelvic lymph node metastasis,deep cervical stromal invasion, intravascular cancer emboli, histological grading, vaginal stump and positivesurgical margin.
Results: The cancer disappearance and superficial muscle invasion rates were statisticallysignificantly better in the concurrent chemoradiotherapy group than in the other two groups (P<0.01). Nostatistically significant difference was noted in the deep muscle invasion rate, surgical time and intraoperativeblood loss among three groups, but significantly more postoperative complications occurred in the concurrentchemoradiotherapy group. The 2-year pelvic recurrence was statistically significantly lower in the concurrentchemoradiotherapy group compared to other two groups, while the 5-year survival was higher.
Conclusion:Concurrent chemoradiotherapy is efficacious for young patients with stage Ib2 cervical cancer.