Predictive Role of Glutathione-S-transferase Gene Polymorphisms in the Survival of Gastric Cancer Cases


Aim: We conducted a prospective study in an Chinese population to detect the association between GSTM,GSTT and GSTP gene polymorphisms and survival of gastric cancer.
Methods: A prospective follow-up studywith 317 gastric cancer patients was conducted between January 2003 and January 2005. GSTM1, GSTT1 andGSTP1 genotyping was performed using ABI TaqMan Gene Expression assays.
Results: Of 317 patients, 5 werelost to follow-up due to migration, while the remaining 302 patients completed the study. The median follow-uptime was 34.2 months (range: 2 to 60 months), during which a total of 120 (39.1%) died of gastric cancer. TheGSTT1-null genotype showed a significant increased risk of death from gastric cancer, with an HR (95% CI) of1.59 (1.04-3.58). Moreover, we found individuals carrying null-GSTM1 and null-GSTT1 had a moderate higherrisk of death from gastric cancer, with an HR of 1.92 (1.05-3.65).
Conclusion: This study reported the carriage ofnull GSTT1 and null GSTM1 might be linked to the higher death risk from gastric cancer in Chinese population.