Objective: The aim of this meta-analysis is to evaluate associations between LTA-252 A>G and breast cancer(BC). Methods: Electronic searches of several databases were conducted for all online publications. A total of 7studies involving 4,625 BC patients and 4,373 controls were identified. Results: This meta-analysis showed nosignificant association between the LTA-252 A>G polymorphism and BC in overall or Caucasian populations.However, a positive association was found limited to Asian populations. Conclusion: Although there was nosignificant association found between the LTA-252 A>G polymorphism and BC overall, a positive associationwas found in Asian populations.