ADPRT Val762Ala and XRCC1 Arg194Trp Polymorphisms and Risk of Gastric Cancer in Sichuan of China

Objective: Gastric cancer remains a major health problem in China. We hypothesized that XRCC1 Arg194Trpand ADPRT Val762Ala may be associated with risk.
Methods: We designed a multicenter 1:1 matched casecontrolstudy of 307 pairs of gastric cancers and controls between October 2010 and August 2011. XRCC1Arg194Trp and ADPRT Val762Ala were sequenced, and demographic data as well as lifestyle factors werecollected using a self-designed questionnaire.
Results: Individuals carrying XRCC1 Trp/Trp or Arg/Trp variantgenotype had a significantly increased risk of gastric cancer (OR, 1.718; 95% CI, 1.190-2.479), while the ORfor ADPRT Val762Ala variant genotype (Ala/Ala or Val/Ala) was 1.175 (95% CI, 0.796-1.737). No gene-gene orgene-environment interactions were found. In addition, family history of cancer and drinkers proportion werehigher among cases than among controls (P<0.05).
Conclusions: XRCC1 194 Arg/Trp or Trp/Trp genotype,family history of cancer, and drinking are suspected risk factors of gastric cancer from our study. Our findingsmay offer insight into further similar large gene-environment and gene-gene studies in this region.