P53 Arg72Pro Polymorphism and Bladder Cancer Risk - Metaanalysis Evidence for a Link in Asians but not Caucasians


Objective: Individual studies of the associations between P53 codon 72 polymorphism (rs1042522) and bladdercancer susceptibility have shown inconclusive results. To derive a more precise estimation of the relationship,we performed this systemic review and meta-analysis based on 15 publications.
Methods: We used odds ratios(ORs) with 95% confidence intervals (CIs) to assess the strength of the association.
Results: We found that therewas no association between P53 codon 72 polymorphism and bladder cancer risk in the comparisons of Pro/Pro vs Arg/Arg; Pro/Arg vs. Arg/Arg; Pro/Pro plus Pro/Arg vs. Arg/Arg; Arg/Arg vs. Pro/Arg plus Arg/Arg(OR=1.06 95%CI 0.81-1.39; OR=1.06 95%CI 0.83-1.36; OR=0.98 95%CI 0.78-1.23; OR=1.06 95%CI 0.84-1.32).However, a significantly increased risk of bladder cancer was found among Asians in the homozygote comparison(Pro/Pro vs. Arg/Arg, OR=1.36 95%CI 1.05-1.75, P=0.790 for heterogeneity) and the dominant model (Arg/Proplus Pro/Pro vs. Arg/Arg, OR=1.26 95%CI 1.05-1.52, P=0.564 for heterogeneity). In contrast, no evidence of anassociation between bladder cancer risk and P53 genotype was observed among Caucasian population in anygenetic model. When stratifying for the stage of bladder, no statistical association were found (Pro/Pro vs. Arg/Arg, OR=0.45 95%CI 0.17-1.21; Pro/Arg vs. Arg/Arg, OR=0.60 95%CI 0.28-1.27; Dominant model, OR=0.5695%CI 0.26-1.20; Recessive model, OR=0.62 95%CI0.35-1.08) between P53 codon 72 polymorphism and bladdercancer in all comparisons.
Conclusions: Despite the limitations, the results of the present meta-analysis suggestthat, in the P53 codon 72, Pro/Pro type and dominant mode might increase the susceptibility to bladder cancerin Asians; and there are no association between genotype distribution and the stage of bladder cancer.