Association of Genetic Polymorphisms at 1q22 but not 10q23 with Gastric Cancer in a Southern Chinese Population


Objective: Data from a recent genome-wide association studiesy of gastric cancer (GC) and oesophagealsquamous cell carcinoma in Chinese living in the Taihang Mountains of north-central China suggest that 1q22and 10q23 are susceptibility-associated regions for GC. However, this has not been confirmed in southernChinese populations. The aim of this study was to investigate whether these polymorphisms at 1q22 and 10q23are associated with the risk of GC in a southern Chinese population.
Methods: We selected seven top significantassociated single nucleotide polymorphisms (SNPs) at 1q22 and 10q23 and conducted a population-based casecontrolstudy in a southern Chinese population. Genotypes were determined using MassARRAYTM system(Sequenome, San Diego, CA).
Results: Two SNPs at 1q22, rs4072037 and rs4460629, were significantly associatedwith a reduced risk of GC, best fitting the dominant genetic model. Logistic regression models adjusted for ageand sex showed that rs4072037 AG and GG (OR=0.64, P=0.017, compared with AA) and rs4460629 CT and TT(OR=0.54, P=0.0016, compared with TT) significantly reduced the risk of GC. However, no significant results forthe five SNPs at 10q23 were obtained in this study.
Conclusion: These outcomes indicate that 1q22 is associatedwith GC susceptibility in this southern Chinese population, while an association for the locus at 10q23 was notconfirmed.