Case-control Study of Single Nucleotide Polymorphisms of PSCA and MUC1 Genes with Gastric Cancer in a Chinese


Aims: A case-control study of 300 gastric cancer patients and 300 controls was conducted to investigatewhether the polymorphisms rs2294008 in PSCA and rs2070803 in MUC1 might be associated with risk of gastriccancer in a Chinese population.
Methods: Single nucleotide polymorphisms (SNPs) were genotyped using theSequenom MassARRAY platform.
Results: The data showed that the rs2294008 TT genotype increased gastriccancer risk to an adjusted odds ratio (OR) of 2.26 (95%CI 1.25-4.07), TC to 1.72 (95%CI 1.23-2.42) and TC/TTto 1.81 (95% CI 1.31-2.50), while the rs2070803 GA genotype was associated with a decrease in risk to an adjustedOR of 0.42 (95% CI 0.28-0.62) and rs2070803 GA / AA to 0.46 (95% CI 0.32-0.67). Further stratification analysisrevealed that rs2294008 in PSCA consistently increased risk of both intestinal and diffuse-type gastric cancers.The effect of rs2070803 in MUC1 was noteworthily also consistent with both subtypes.
Conclusions: Our studysuggested rs2294008 in the PSCA gene to be associated with increased risk of gastric cancer and rs2070803 inMUC1 to play a protective role in a Chinese population.