Quantitative Assessment of the Effects of MMP-2 Polymorphisms on Lung Carcinoma Risk


Background: Previous studies assessing associations between matrix metalloproteinase 2 (MMP-2)polymorphisms and lung cancer risk reported conflicting results. A meta-analysis was therefore performed toderive a more precise estimation.
Method: Case-control studies assessing associations between MMP-2 C735Tand C1306T polymorphisms and lung cancer risk were included. Pooled odds ratios (ORs) with 95% confidenceintervals (CIs) were estimated.
Results: 7 studies with a total of 3,189 lung cancer cases and 3,013 controls werefinally included into this meta-analysis. Overall, the MMP-2 C735T polymorphism was associated with lungcancer risk under the homozygote model (CC versus TT: OR =1.44, 95% CI = 1.03-2.02, I2 = 0%), while the MMP-2 C1306T polymorphism also associated demonstrated links with all four models (all P values less than 0.05).Subgroup analyses by race suggested obvious associations between MMP-2 C735T and C1306T polymorphismsand lung cancer risk in Asians but not in Caucasians. There was no evidence for publication bias.
Conclusion:Currently available evidence supports teh conclusion that MMP-2 C735T and C1306T polymorphisms influencesusceptibility to lung cancer in Asians.