p.R72P, PIN3 Ins16bp Polymorphisms of TP53 and CCR5Δ32 in North Indian Breast Cancer Patients

Background: The present study aimed to find the prognostic implications of two polymorphisms in TP53(p.R72P, PIN3 Ins16bp) and one in CCR5 (CCR5Δ32) in sporadic breast cancer patients.
Methods: DNA samplesof 80 breast cancer patients and 80 age and gender matched unrelated healthy control individuals from Punjab,North West India were analyzed.
Results: For p.R72P, the genotype frequency was 13.8% (RR), 58.8% (RP),27.5% (PP) in patients and 33.9% (RR), 40.0% (RP), 26.5% (PP) in controls. For PIN3 Ins16bp, the genotypefrequencies were 53.75% (A1A1), 37.5% (A1A2), 8.75% (A2A2) in patients and 66.3% (A1A1), 31.3% (A1A2),2.5% (A2A2) in controls. Only 4 (5%) breast cancer patients were heterozygous for CCR5Δ32 deletion. CommonRR-A1A1-WT/WT genotype was lower while RP-A1A2-WT/WT genotype was higher in patients as comparedto controls. RP-A1A1-WT/WT genotype was significantly higher in patients as compared to control individuals(p = 0.008).
Conclusion: Though a clear association of any particular genotype with sporadic breast cancer orstage was not apparent, the results of present study were suggestive that sporadic breast cancer patients withRR-A1A1-WT/WT genotype might have a better response to chemotherapy, thus improving their chances ofsurvival.