The aim of the present investigation was to evaluate the effect of A.nilotica extract against Dalton’s asciticlymphoma (DAL) induced solid and ascitic tumors in BALB/c mice. Experimental animals received A.niloticaextract (10 mg/kg.bw) intraperitoneally for 10 and 14 consecutive days before induction of solid and ascitictumors, respectively. Treatment with A.nilotica extract significantly decreased the development of tumor andpercentage increase in body weight when compared to DAL induced solid tumor control group, also increasing thelife span, restoring the total white blood cell count and hemoglobin content and significantly decreasing the levelsof serum aspartate transaminase (SGPT), alanine transaminase (SGOT), alkaline phosphatase (ALP), gammaglutamyl transferase (GGT) and nitric oxide (NO) when compared to DAL induced ascitic tumor controls. Thetreatment also reduced significantly the cellular glutathione (GSH) and nitric oxide levels in treated animals.Histopathological studies also confirmed protective influence. The outcome of the present work indicates thatA.nilotica extract could be used as natural anticancer agent for human health.