Retrospective Analysis of 498 Primary Soft Tissue Sarcomas in a Single Turkish Centre

Background: Soft tissue sarcomas (STS) must be managed with a team involving pathologists, radiologists,surgeons, radiation therapists and medical oncologists. Treatment modalities and demographic charasteristics ofTurkish STS were analysed in the current study. Material-
Methods: Primary adult STS followed between 1999-2010 in Cukurova University Medical Faculty Department of Medical Oncology were analzied retrospectively
Results: Of the total of 498 patients, 238 were male and 260 female. The most seen adult sarcomas wereleomyosarcoma (23%). Localization of disease was upper extremity (8.8%), lower extremity (24.7%), head-neck8.2%, thoracic 8%, retroperitoneal 5.6%, uterine 12.4%, abdominal 10%, pelvic region 3.6 and other regions10%. Some 13.1% were early stage, 10.2% locally advanced, 8.2% metastatic and 12.2% recurrent disease.Patients were treated with neoadjuvant/adjuvant (12%) or palliative chemotherapy (7.2%) and 11.4% patientsdid not receive chemotherapy. Surgery was performed as radical or conservative. The most preferred regimen wasMAID combination chemotherapy in the rate of 17.6%. The most common metastatic site was lung (18.1%). Theoverall survival was 45 months (95%CI 30-59), 36 months in men and 55 months in women, with no statisticallysignificant difference (p=0.5). The survival rates were not different between the group of adjuvant and palliativechemotherapy (respectively 28 versus 18 months) (p=0.06), but radical surgery at 37 months was better than22 months for conservative surgery (p=0.0001). No differences were evident for localization (p=0.152). Locallyadvanced group had higher overall survival rates (72 months) than other stages (p=0.0001).
Conclusion: STScan be treated successfully with surgery, chemotherapy and radiotherapy. The survival rates of Turkish peoplewere higher in locally advanced group; these results show the importance of multimodality treatment approachand radical surgery.