With the advances in modern diagnostic expertise for cancer, certain approaches allowing scanning of thecomplete genome and the proteome are becoming very useful for researchers. These high throughput techniqueshave already proven power, over traditional detection methods, in differentiating disease sub-types and identifyingspecific genetic events during progression of cancer. This paper introduces major branches of omics-technologyand their applications in the field of cancer. It also addresses current road blocks that need to be overcome andfuture possibilities of these methods in oncogenic detection.