The aim of this study was to investigate QoL (quality of life) of patients with esophageal cancer in northernHenan province, China, and to accurate evaluate and reflect the relationship between patient characteristics andQoL. In the high risk area of esophageal cancer in the north of Henan province, 735 patients with esophagealcancer were investigated. The Eysenck personality questionnaire (EPQ) and QoL were analyzed by using thequestionnaire of general situation, EPQ, QLQ-C30 and QLQ-OES18. The effects of personal character on theQoL of esophageal carcinoma patients were analyzed by SPSS 11.0 software. The QoL of esophageal cancerpatients in Northern Henan region was significantly affected by character. The difference between choleric andtype of melancholic temperament types was significant (P<0.01), also in OESEAT, OESTA, OESCO and OESSP(P<0.05). Differences in personal character can thus influence the quality of esophageal cancer patient lives.