Polymorphisms of XRCC1 and ADPRT Genes and Risk of Noncardia Gastric Cancer in a Chinese Population: a Casecontrol Study

Objective: Gastric cancer (GC) is one of the most common malignancies and its mortality ranks third amongall cancers in China. We previously noted that XRCC1 Arg194Trp was associated with GC risk in WesternChina in a study on XRCC1 Arg194Trp and ADPRT Val762Ala. We aimed to further explore the associationof these polymorphisms with risk of the noncardia subtype.
Methods: We enrolled 176 noncardia GC patientsand 308 controls from four hospitals and a community between October 2010 and August 2011. Genotyping wasperformed in a 384-well plate format on the Sequenom MassARRAY platform. A self-designed questionnairewas utilized to collect epidemiological data from the subjects regarding demographic factors and potential riskfactors.
Results: Subjects were aged 56.8±11.8 (mean ± standard deviation) and 57.6±11.1 years in the caseand control groups, respectively. Individuals carrying the XRCC1 Trp/Trp or Arg/Trp variant genotype wereat significantly increased risk of noncardia GC (adjusted OR, 1.48; 95% CI, 1.00-2.17), after adjustment forfamily history of cancer, drinking, and smoking. The increased risk of XRCC1 Arg194Trp variant genotypewas more pronounced among subjects below 60 years old (adjusted OR, 1.78; 95% CI, 1.07-2.96), comparedto older individuals. ADPRT Val762Ala variants (Ala/Ala or Val/Ala) were not associated with noncardia GC(adjusted OR, 1.03; 95% CI, 0.69-1.54).
Conclusions: Our study suggests that XRCC1 Arg194Trp is a geneticsusceptibility factor for developing noncardia GC in Han Chinese in Western China. In particular, individualswith the XRCC1 Arg194Trp variant genotype are at increased risk for GC below 60 years old.