Association of TNF-α-308 and -238 Polymorphisms with Risk of Cervical Cancer: A Meta-analysis

Published data on the associations between tumor necrosis factor-alpha (TNF-α) promoter -308G>A and-238G>A polymorphisms and cervical cancer risk are inconclusive. To derive a more precise estimation of therelationship, a meta-analysis was performed. Data were collected from MEDLINE and PubMed databases.Crude odds ratios (ORs) with 95% confidence intervals (CIs) were calculated in a fixed/random effect model.13 separate studies including 3294 cases and 3468 controls were involved in the meta-analysis. We found noassociation between TNF-α-308G>A polymorphism and cervical cancer in overall population. In subgroupanalysis, significantly elevated risks were found in Caucasian population (A vs. G: OR = 1.43, 95% CI = 1.00-2.03; AA vs. GG: OR = 2.09, 95% CI = 1.34-3.25; Recessive model: OR = 2.09, 95% CI = 1.35- 3.25) and Africanpopulation (GA vs. GG: OR = 1.53, 95% CI = 1.02-2.30). An association of TNF-α-238G>A polymorphism withcervical cancer was found (A vs. G: OR = 0.61, 95% CI = 0.47-0.78; GA vs. GG: OR = 0.59, 95% CI = 0.45-0.77;Dominant model: OR = 0.59, 95% CI = 0.46-0.77). When stratified by ethnicity, similar association was observedin Caucasian population (A vs. G: OR = 0.62, 95% CI = 0.46-0.84; GA vs. GG: OR = 0.59, 95% CI = 0.43-0.82;Dominant model: OR = 0.60, 95% CI = 0.44-0.83). In summary, this meta-analysis suggests that TNF-α-238Aallele significantly decreased the cervical cancer risk, and the TNF-α-308G>A polymorphism is associated withthe susceptibility to cervical cancer in Caucasian and African population