Abstract
Background/Aim: Six prostate cancer (PCa) susceptibility loci were identified in a genome-wide associationstudy (GWAS) in populations of European decent. However, the associations of these 6 single-nucleotidepolymorphisms (SNPs) with PCa has remained tobe clarified in men in Northern China. This study aimedto explore the loci associated with PCa risk in a Northern Chinese population.
Methods: Blood samples andclinical information of 289 PCa patients and 288 controls from Beijing and Tianjin were collected. All risk SNPswere genotyped using polymerase chain reaction (PCR)-high resolution melting curve technology and genesequencing. Associations between PCa and clinical covariates (age at diagnosis, prostate-specific antigen [PSA],Gleason score, tumor stage, and level of aggressiveness) and frequencies of alleles and genotypes of these SNPswere analyzed using genetic statistics.
Results: Among the candidate SNPs, 11p15 (rs7127900, A) was associatedwith PCa risk (P = 0.02, odds ratio [OR] = 1.64, 95% confidence interval [CI] = 1.09–2.46). Genotypes showeddifferences between cases and controls on 11p15 (rs7127900, A), 11q13 (rs7931342, T), and HNF1B (rs4430796,A) (P = 0.03, P = 0.01, and P = 0.04, respectively). The genotype TG on 11q13 (rs7931342, T) was positivelyassociated with an increased Gleason score (P = 0.04, OR = 2.15, 95% CI = 1.02–4.55). Patients carrying TG on17q24 (rs1859962, G) were negatively associated with an increased body mass index (BMI) (P = 0.03, OR = 0.44,95% CI = 0.21–0.92) while those with AG on HNF1B (rs4430796, A) were more likely to have PSA increase (P= 0.002).
Conclusion: Our study suggests that 11p15 (rs7127900, A) could be a susceptibility locus associatedwith PCa in Northern Chinese. Genotype TG on 11q13 (rs7931342, T) could be related to an increased Gleasonscore, AG on HNF1B (rs4430796, A) could be associated with PSA increase, and TG on 17q24 (rs1859962, G)could be negatively associated with an increased BMI in Chinese men with PCa.
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