Ovarian Transposition for Stage Ib Squamous Cell Cervical Cancer - Lack of Effects on Survival Rates?

Background: To investigate the impact of ovarian transposition (OT) on survival rates of the patients withstage Ib squamous cell cervical cancer. Materials and
Methods: Ninety-two subjects who underwent a radicalhysterectomy including oophorectomy were evaluated. For nineteen (20.7%) , OT was performed. Patients weredivided into two groups, OT versus oophorectomy alone. The primary end-point of this study was to investigatethe impact of OT on tumor recurrence rate and time, 5-year disease-free survival (DFS) and overall survival(OS) . These comparisons were performed for subgroups including patients who received radiotherapy versuswho did not. Statistical analyses were conducted using the Chi-square test, T-test and Mann-Whitney test. OSwas examined using the Kaplan-Meier method. P≤0.05 was considered to be statistically significant.
Results:The median follow-up period was 89 months for OT and 81 months for the oophorectomy group (p>0.05). Bothgroups experienced similar recurrence rates (31.6% vs. 26.4%, p=0.181). The median duration from surgery torecurrence, and surgery to death were also similar between the groups (p>0.05). The 5-year DFS and OS rateswere both 68.4% for the OT group, and 73.6% and 77.8% for the oophorectomy group (p=0.457 and p=0.307,respectively). While the 5-year DFS rate was not statistically significant between the OT and oophorectomy groupswho did not receive radiotherapy (p=0.148), the 5-year OS rate was significantly higher in the oophorectomy group(95.4% vs 66.7%, respectively) without radiotherapy (p=0.05). The 5-year DFS and OS rates were statisticallysimilar between the groups who received adjuvant radiotherapy (p>0.05).
Conclusions: Ovarian transpositionhas not significantly negative effect on the survival rates when adjuvant radiotherapy will be applied, while5-year OS may be less in OT group if radiotherapy is not mandatory.