Human Papilloma Virus Frequency and Genotype Distributionin a Turkish Population


Objectives: To determine human papillomavirus (HPV) frequency, genotypes and the relation betweencervical smear results, risk factors and types in women living in Manisa, Turkey. Materials and
Methods: A totalof 410 women were included in the study. Cervical specimens were obtained for linear array HPV genotypingand pathological testing. Conventional Pap test and Bethesda system were used for evaluation of cytologyspecimens.
Results: A total of 410 women with a mean age of 34.9 years were tested. A positive result of anyHPV was found in 35 patients (8.5%). Among them, 26 different serotypes of HPV were identified and the mostfrequent type was HPV 16 (28.5%) followed by type 45 and 53 (11.4%). Patients were infected by 65.7% highrisk, 11.4% probable high risk and 22.9% low risk HPV types. Multiple HPV positive results were found in13 patients (37.1%). Patients with single partner, history of abnormal smear or condyloma had positive HPVresults and this was statistically significant (p<0.05). Correlation analysis showed a statistically weak relationbetween positive HPV and abnormal smear results (r=0.120).
Conclusions: Determining HPV types of genitalHPV infections is important for epidemiological studies. We have found the rate of positive HPV as 8.5% whichimplies the need for extended screening programs in order to diagnose oncogenic HPV at an early stage.