Lack of Relationships between FGF19 Staining Pattern, Lymph Node Metastasis and Locally Invasive Characteristics of the Tumor in Colorectal Cancers

Introduction: Colorectal cancers are in the top of the cancer-related causes of death in the world and lymphnode metastasis is accepted as the primary prognostic factor. In this study, correlations of FGF19 staining patternwith local invasion and lymph node metastasis in a series of colorectal cancers were investigated.
Methods:This studyincluded 81 colorectal cancer patients who underwent surgery in our hospital with no evidence ofpreoperative radiological distant metastasis. Routine pathological examination of the resection material wasperformed in order to identify vascular, perineural and serosal infiltration, regional lymph node metastasis andthe degree of differentiation. Tumor tissue samples were stained with an immunohistochemistry method forFGF 19 evaluation and the staining pattern was statistically compared with the above mentioned characteristicsof the tumors.
Results: The patient population consisted of 47 females and 34 males with a median age of 70years. In 40 patients regional lymph nodes were positive and 51%, 32% and 38% had serosal, perineural andvascular invasion. While 64 cases were moderately-differentiated, 11 cases were well-differentiated and 6 poorlydifferentiated,there was no association with FGF 19 staining, including intensity.
Conclusion: No evidence ofsignificant statistically correlation was found between FGF 19 staining pattern and serosal, perineural, vascularinvasion, lymph node involvement and degree of differentiation.