Single Nucleotide Polymorphisms in the u-PA Gene are Relatedto Susceptibility to Oral Tongue Squamous Cell Carcinoma inthe Northern Chinese Han Population

Aim: The purpose of this study was to determine whether susceptibility to oral tongue squamous cellcarcinoma (OSCC) is related to polymorphisms in the u-PA gene.
Methods: We examined the rs2227564 C/Tand rs2227562 G/A single nucleotide polymorphisms (SNPs) in 196 OSCC patients and 201 age- and gendermatchedcontrols via direct sequencing and PCR-RFLP methods.
Results: Significant differences were found inallelic and genotypic distributions of the rs2227564 and rs2227562 loci when comparing cases and controls. Inaddition, logistic analyses indicated that the rs2227564 C/T genotype was related to a 1.52-fold increased riskof developing OSCC (adjusted OR=1.521, 95%CI: 1.144~2.022, P=0.004). Linkage disequilibrium analysis wasconducted and no association between the two loci was found (D’=0.031, r2=0.000).
Conclusions: Our findingsprovide evidence that the rs2227564 C/T SNP in the u-PA gene is associated with the development of OSCC.