microRNAs (miRNAs) are small non-coding RNAs that regulate gene expression through post-transcriptionalinteractions with mRNA. miRNAs have recently emerged as key regulators of various cancers. Although miR-27a has been implicated in several other cancers, its role in hepatitis B virus-related hepatocellular carcinoma(HCC) is unknown. In this study, we showed miR-27a to be frequently up-regulated in HCC tissues and HCCcell lines (HepG2 and Huh7). Overexpression of miR-27a enhanced cell proliferation, promoted migration andinvasion, and activated cell cycling in HepG2 and Huh7 cells. In summary, our results suggest that up-regulationof miR-27a may play an oncogenic role in the development of HCC and might thus be a new therapeutic targetin HCC patients.
(2013). miR-27a as an Oncogenic microRNA of Hepatitis B VirusrelatedHepatocellular Carcinoma. Asian Pacific Journal of Cancer Prevention, 14(2), 885-889.
MLA
. "miR-27a as an Oncogenic microRNA of Hepatitis B VirusrelatedHepatocellular Carcinoma". Asian Pacific Journal of Cancer Prevention, 14, 2, 2013, 885-889.
HARVARD
(2013). 'miR-27a as an Oncogenic microRNA of Hepatitis B VirusrelatedHepatocellular Carcinoma', Asian Pacific Journal of Cancer Prevention, 14(2), pp. 885-889.
VANCOUVER
miR-27a as an Oncogenic microRNA of Hepatitis B VirusrelatedHepatocellular Carcinoma. Asian Pacific Journal of Cancer Prevention, 2013; 14(2): 885-889.
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