Hepatitis B Virus Gene C1653T Polymorphism Mutation andHepatocellular Carcinoma Risk: an Updated Meta-analysis

Although there have been many studies investigating possible associations between the C1653T mutation andrisk of HCC, the results have been inconsistent. We conducted searches of the published literature in Pubmedand Embase databases up to January 2013. Seventeen studies with a total of 1,085 HCC cases and 1,365 healthycontrols were retrieved.We found a significant association between the C1653T mutation and HCC risk (OR =2.01, 95%CI= 1.49–2.70). In the subgroup analysis by ethnicity, a significant association was also found in Asians(OR = 2.07, 95%CI= 1.71–2.51). In subgroup analysis by HBV genotype, B and C were linked with developmentof HCC (B:OR = 2.21, 95%CI= 1.13–4.34; C:OR = 2.26, 95%CI= 1.61–3.16). However, no significant associationwas found between the C1653T mutation and HCC risk in HBeAg positive cases. In conclusion, this meta-analysissuggests that the C1653T mutation may be associated with susceptibility to HCC.