Background: p53 gene variants i.e. 16 bp duplication in intron 3, Arg72Pro in exon 4 and G>A in intron 6have been reported to modulate susceptibility to various malignancies. Therefore, the present study evaluatedthe role of these p53 polymorphisms in oral cancer susceptibility in a population from Gujarat, West India. Method: Genotype frequencies at the three p53 loci in 110 controls and 79 oral cancer cases were determinedby the PCR-RFLP method. Results: Heterozygous individuals at exon 4 showed protection from developingoral cancer. Homozygous wild and heterozygous individuals at intron 3 and those heterozygous at exon 4 incombination appeared to be at lowered risk. Furthermore, carriers of the 16 bp duplication allele at intron 3,proline allele at exon 4 and G allele at intron 6 were protected from oral cancer development. Conclusion: p53polymorphisms, especially Arg72Pro in exon 4 could significantly modify the risk of oral cancer developmentin Gujarat, West Indian population.
(2013). Association between p53 Gene Variants and Oral CancerSusceptibility in Population from Gujarat, West India. Asian Pacific Journal of Cancer Prevention, 14(2), 1093-1100.
MLA
. "Association between p53 Gene Variants and Oral CancerSusceptibility in Population from Gujarat, West India". Asian Pacific Journal of Cancer Prevention, 14, 2, 2013, 1093-1100.
HARVARD
(2013). 'Association between p53 Gene Variants and Oral CancerSusceptibility in Population from Gujarat, West India', Asian Pacific Journal of Cancer Prevention, 14(2), pp. 1093-1100.
VANCOUVER
Association between p53 Gene Variants and Oral CancerSusceptibility in Population from Gujarat, West India. Asian Pacific Journal of Cancer Prevention, 2013; 14(2): 1093-1100.