Hypothesis on the Role of Cytoplasmic “Short Base Sequences”in Carcinogenesis

Abstract

Cancer is a highly complex medical problem with ramifications for public health throughout the world. Moststudies have mainly focused on change in the nuclei as being aetiologically responsible. Few have examined therelationship between the cytoplasm and cancer, despite the fact that research has indicated that the cytoplasmicenvironment is an important factor for cellular differentiation and that the genetic information provided by thenucleus is entirely dependent on this environment for its expression. Gene mutations may be the result, ratherthan the cause of carcinogenesis. We submit a new concept - “short base sequences” (50-500 bps, including DNAor RNA sequences) in the cytoplasm which could play an important role in carcinogenesis. This is a new theoryto explain the origin of the cancer.

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