No Association Between Tea Consumption and Risk of RenalCell Carcinoma: A Meta-analysis of Epidemiological Studies

Objective: To evaluate the association between tea consumption and the risk of renal cell carcinoma.
Methods: We searched PubMed,Web of Science and Scopus between 1970 and November 2012. Two evaluatorsindependently reviewed and selected articles based on predetermined selection criteria.
Results: Twelveepidemiological studies (ten case-control studies and two cohort studies) were included in the final analysis. Ina meta-analysis of all included studies, when compared with the lowest level of tea consumption, the overallrelative risk (RR) of renal cell carcinoma for the highest level of tea consumption was 1.03 (95% confidenceinterval [CI] 0.89–1.21). In subgroup meta-analyses by study design, there was no significant association betweentea consumption and renal cell carcinoma risk in ten case-control studies using adjusted data (RR=1.08, 95% CI0.84–1.40). Furthermore, there was no significant association in two cohort studies using adjusted data (RR=0.95,95% CI 0.81–1.12).
Conclusion: Our findings do not support the conclusion that tea consumption is related todecreased risk of renal cell carcinoma. Further prospective cohort studies are required.