Treatment Outcomes of Paclitaxel for Refractory or Recurrent Epithelial Ovarian Cancer Patients in Thailand

Background: To study the response rate, toxicity profiles, and survival of refractory or recurrent epithelialovarian cancer (EOC) patients treated with paclitaxel. Materials and
Methods: Patients with refractory orrecurrent EOC who were treated with paclitaxel between January 2002 and December 2011 at the Departmentof Obstetrics and Gynecology, Faculty of Medicine, Vajira Hospital were identified. Clinicopathological featuresof the patients including detailed data of paclitaxel treatment were collected.
Results: During the study period, atotal of 44 patients were identified, with a mean age of 52.9±8.2 years. Some 13.6% (six patients) had refractorycancer to first-line chemotherapy while 86.4% (38 patients) had recurrent cancer. Among these, 35 (79.6%)and 9 (20.4%) patients were considered as platinum-sensitive and platinum-resistant, respectively. Threepatients (6.8%) received fewer than 2 cycles of paclitaxel due to loss to follow-up, leaving 41 patients evaluablefor response. The overall response rate observed in all 41 patients was 41.5% (17 patients; 12 complete andfive partial responses): 12.5% or 1/8 patients with refractory or platinum-resistant cancer and 48.5% or 16/33patients with platinum-sensitive disease. Stable disease was demonstrated in 17.0% (seven patients) whileprogressive disease was apparent in 41.5% (17 patients). Median time to progress was 4.5 months (range, 0.67-58.6 months). Median progression-free survival was not reached while median overall survival was 16.3 months(95% confidence interval, 11.0 months -21.6 months). Common toxicities were neutropenia, neuropathy, andalopecia.
Conclusions: Paclitaxel is an active agent for refractory or recurrent EOC. Neutropenia, neuropathyand alopecia are common side effects.