Investigation of the Antioxidant Status in Multiple Myeloma Patients: Effects of Therapy

Background: Multiple myeloma is a malignant silent incurable plasma cell disorder. The present study aimedto assessed the activation of the oxidative stress pathway in afected patients Materials and
Methods: Advancedoxidation protein products (AOPPs), malondialdehyde (MDA), adenosine deaminase (ADA), total antioxidantcapacity (TAC) levels, glutathione, ascorbic acid (vitamin C), α-tocopherol (vitamin E) in addition to relatedenzymes glutathione peroxidase (GSH-Px), glutathione reductase (GSH-R) and superoxide dismutase (SOD)were analyzed in sixty patients with multiple myeloma before and after one month treatment with inductiontherapy.
Results: The results of the study showed a significant elevation in AOPPs, MDA, ADA levels in patientswith multiple myeloma before and after treatment in comparison to healthy control samples In contrast TACglutathione, vitamin C and E, and the antioxidant enzymes levels were decreased significantly. On comparingsamples of MM patients after treatment, there was significant increase of TAC glutathione, vitamin C and E, andthe antioxidant enzymes in parallel with decreasing AOPPs, MDA and ADA levels in comparison with samples ofpatients before treatment.
Conclusions: The results indicate oxidative stress and DNA damage activity increasein MM and are alleviated in response to therapy.