Expressional Correlation of Human Epidermal Growth Factor Receptor 2, Estrogen/Progesterone Receptor and Protein 53 in Breast Cancer

Background: This study aimed to show the localization of estrogen / progesterone receptors, human epidermalgrowth factor receptor 2 (Her-2) and protein 53 (p53) by immunohistochemistry in a series of consecutive breastcancer patients. Materials and
Methods: The study covered invasive breast cancers from 299 patients presentingat the Oncogenetic Clinic and Pathology Centers of Ahwaz Jondishapour University of Medical Sciences Hospitalin Iran during the time period from 2009 to 2011. The Scarff-Bloom Richardson scoring method was used.
Results:Of the 299, 27% (80/299) were <40, 33% (100/299) were 41-50, and the remaining 40% (119/299) were>50 yearsold. The highest incidence of breast cancer in this study population was in the group of more than 50 year age,and the most common histological type of breast cancer was the invasive ductal carcinoma, which accountedfor 68% (203/299) of the cases. Out of possible total of 207, 6% (13/207), 41% (85/207), and 53% (109/207) werescored as grade І, ІІ, ІІІ, respectively.
Conclusion: Our findings demonstrated a lack of association betweenlabeling for the markers studied and tumor size and age of the patients. We confirmed an association betweenER labeling and nuclear grade of breast cancer. The conflicting results obtained compared with the literature bebecause of differences in the immunohistochemical techniques applied in the various studies and to the scoringsystems used.