Association of XRCC1 Gene Polymorphisms with Breast Cancer Susceptibility in Saudi Patients

Background: X-ray repair cross-complementing group 1 (XRCC1) plays a key role in the base excision repairpathway, as a scaffold protein that brings together proteins of the DNA repair complex. XRCC1 is reported tobe a candidate influence on cancer risk. The aim of our present study was to assess the association of rs1799782(Arg194Trp) and rs25487 (Arg399Gln) XRCC1 gene polymorphisms with breast cancer in the Saudi population.Materials and
Methods: The two SNP’s were analyzed in breast cancer patients and healthy control subjects.Genotypes were determined by TaqMan SNP genotype analysis technique and data were analyzed using Chisquareor t test and logistic regression analysis by SPSS16.0 software. Results and
Conclusions: Results showedthat rs1799782 significantly increased susceptibility to breast cancer with Arg/Trp, Arg/Trp+Trp/Trp genotypesand at Trp allele overall study. It also increased risk of breast cancer in older age patients (above 48) and withthe ER positive category. XRCC1rs25487 (Arg399Gln) did not showed any significant association. In conclusionthe XRCC1rs1799782 polymorphism may be involved in the etiology of breast cancer in the Saudi population.Confirmation of our findings in larger populations of different ethnicities is warranted.