Relationships between Skin Cancers and Blood Groups - Link between Non-melanomas and ABO/Rh Factors

Background: This investigation focused on possible relationships between skin cancers and ABO/Rh bloodgroups. Materials and
Methods: Between January 2005 and December 2012, medical data of 255 patients withskin cancers who were admitted to Kayseri Training and Research Hospital, Radiation Oncology and PlasticSurgery Outpatient Clinics were retrospectively analyzed. Blood groups of these patients were recorded. Thecontrol group consisted of 25701 healthy volunteers who were admitted to Kayseri Training and ResearchHospital, Blood Donation Center between January 2010 and December 2011. The distribution of the blood groupsof the patients with skin cancers was compared to the distribution of ABO/Rh blood groups of healthy controls.The association of the histopathological subtypes of skin cancer with the blood groups was also investigated.
Results: Of the patients, 50.2% had A type, 26.3% had O type, 16.1% had B type, and 7.5% had AB blood groupwith a positive Rh (+) in 77.3%. Of the controls, 44.3% had A type, 31.5% had 0 type, 16.1% had B type, and8.1% had AB blood group with a positive Rh (+) in 87.8%. There was a statistically significant difference in thedistribution of blood groups and Rh factors (A Rh (-) and 0 Rh positive) between the patients and controls. A totalof 36.8% and 20.4% of the patients with basal cell carcinoma (BCC) had A Rh (+) and B Rh (+), respectively,while 39.2% and 27.6% of the controls had A Rh (+) and B Rh (+), respectively. A significant relationship wasobserved between the patients with BCC and controls in terms of A Rh (-) (p=0.001).
Conclusion: Our studyresults demonstrated that there is a significant relationship between non-melanoma skin cancer and ABO/Rhfactors.