Background: Pretreatment serum p53 and epidermal growth factor receptor (EGFR) were assessedusing enzyme-linked immunosorbent assay (ELISA) in patients with acute leukemia to analysis their roles incharacterization of different subtypes of the disease. Materials and Methods: Serum samples from thirty twopatients with acute myeloid leukemia (AML) and fourteen patients with acute lymphoid leukemia (ALL) wereanalysed, along with 24 from healthy individuals used as a control group. Results: The results demonstrateda significant increase of serum p53 and EGFR in patients with AML (p<0.0001) compared to the controlgroup. Also, the results showed a significant increase of both markers in patients with ALL (p<0.05, p<0.0001respectively). Sensitivities and specificities for these variables were 52% and 100% for p53, and 73.9%, 95.8%for EGFR. Serum p53 and EGFR could successfully differentiate between M4 and other AML subtypes, whilethese variables failed to discriminate among ALL subtypes. A positive significant correlation was noted betweenp53 and EGFR. Negative significant correlations were observed between these variables and both of hemoglobin(Hg) content and RBC count. Conclusions: Mutant p53 and EGFR are helpful serological markers for diagnosisof patients with AML or ALL and can aid in characterization of disease. Moreover, these markers may reflectcarcinogenesis mechanisms.
(2013). Clinical Significance of Serum p53 and Epidermal Growth Factor Receptor in Patients with Acute Leukemia. Asian Pacific Journal of Cancer Prevention, 14(7), 4295-4299.
MLA
. "Clinical Significance of Serum p53 and Epidermal Growth Factor Receptor in Patients with Acute Leukemia". Asian Pacific Journal of Cancer Prevention, 14, 7, 2013, 4295-4299.
HARVARD
(2013). 'Clinical Significance of Serum p53 and Epidermal Growth Factor Receptor in Patients with Acute Leukemia', Asian Pacific Journal of Cancer Prevention, 14(7), pp. 4295-4299.
VANCOUVER
Clinical Significance of Serum p53 and Epidermal Growth Factor Receptor in Patients with Acute Leukemia. Asian Pacific Journal of Cancer Prevention, 2013; 14(7): 4295-4299.