B-cell Lymphoma 2 rs17757541 C>G Polymorphism was Associated with an Increased Risk of Gastric Cardiac Adenocarcinoma in a Chinese Population

Aim: Apoptosis has been considered as a fundamental component in cancer pathogenesis, and related geneticfactors might play an important role in gastric cardiac adenocarcinoma (GCA) genesis.
Methods: We conducteda hospital based case–control study to evaluate the genetic effects of functional single nucleotide polymorphisms(SNPs): BCL2 rs17757541 C>G, BCL2 rs12454712 T>C, FAS rs2234767 G>A, FASL/FASLG rs763110 C>T,ERBB2 rs1136201 A>G and VEGFR2/KDR rs11941492 C>T on the development of GCA. A total of 243 GCAcases and 476 controls were recruited for the study and genotypes were determined using a custom-by-design48-Plex SNPscanTM Kit.
Results: The BCL2 rs17757541 C>G polymorphism was associated with increased riskof GCA. However, there was no significant associations with the other five SNPs. Stratified analyses indicateda significantly increased risk of GCA associated with the BCL2 rs17757541 C>G polymorphism among males,older patients and those with a history of smoking or drinking.
Conclusion: These findings indicated that thefunctional polymorphism BCL2 rs17757541 C>G might contribute to GCA susceptibility. However, our resultswere limited by small sample size. Future larger studies are required to confirm our current findings.