No Association of XRCC1 and CLPTM1L Polymorphisms with Non-small Cell Lung Cancer in a Non-Smoking Han Chinese Population

Background: This study aimed to explore potential associations between single nucleotide polymorphisms(SNPs) of the x-ray repair cross-complementing group 1 (XRCC1) and cleft lip and palate transmembrane protein1-like (CLPTM1L) and non-small cell lung cancer (NSCLC) susceptibility in non-smoker Chinese patients.
Methods: A total of 200 NSCLC patients and 200 healthy controls with matched age and gender were recruitedfor genotyping of XRCC1 SNPs (rs2256507 and rs1001581) and CLPTM1L SNPs (rs401681 and rs4975616).Association of these SNPs with NSCLC risk was evaluated by computing the odds ratio (OR) and 95% confidenceinterval (CI) from multivariate unconditional logistic regression analyses with adjustment for gender and age.
Results: The frequencies of genotype and allele in these four loci (rs2256507, rs1001581, rs401681, and rs4975616)were not significantly different between the cases and controls, or between either of the histological subgroups(adenocarcinoma and squamous cell carcinoma) and controls.
Conclusions: Although these SNPs are associatedwith NSCLC risk in patients with a tobacco-smoking habit, this study demonstrated that XRCC1 and CLPTM1Lgene SPNs are not linked with NSCLC risk in non-smoking patients, indicating that molecular mechanisms ofNSCLC betwee tobacco smokers and non-smokers may be different. Future studies are needed to uncover theunderlying molecular mechanisms for NSCLC in non-smokers.