Association of TAP1 and TAP2 Gene Polymorphisms with Hematological Malignancies

Transporter associated with antigen presenting (TAP) 1 and TAP2 genes are localized in the majorhistocompatability complex (MHC) class II region and form a heterodimer playing a key role in endogenouspathways for antigen presentation. Defects of these genes have been reported to be common in different typesof cancer. Polymorphisms identified in these loci have also been investigated and reported to be associated withseveral autoimmune disorders, viral infections and neoplasms. In the present study, for the first time, the alleleand genotype frequencies of TAP1-333, TAP2-565, TAP2-651 and TAP2-665 were determined in patients withhematological malignancies (HM) using a PCR-RFLP method and compared with the frequencies in the controlgroup. Our results suggested an association of TAP1-333 polymorphism with multiple myeloma-MM and TAP2-565 polymorphism with chronic lymphoid leukemia-CLL. In addition, it could be concluded that the TAP2-665GG genotype might be a risk factor for all types of hematological malignancies included in this study.