Clinical Risk Factor Analysis for Breast Cancer: 568,000 Subjects Undergoing Breast Cancer Screening in Beijing, 2009

Objectives: Although there are many reports about the risk of breast cancer, few have reported clinicalfactors including history of breast-related or other diseases that affect the prevalence of breast cancer. This studyexplores these risk factors for breast cancer cases reported in Beijing in 2009. Materials and
Methods: Datawere derived from a Beijing breast cancer screening performed in 2009, of 568,000 women, from 16 districts ofBeijing, all aged between 40 and 60 years. In this study, multilevel statistical modeling was used to identify clinicalfactors that affect the prevalence of breast cancer and to provide more reliable evidence for clinical diagnosticsby using screening data. Results and
Conclusion: Those women who had organ transplants, compared withthose with none, were associated with breast cancer with an odds ratio (OR) = 65.352 [95% confidence interval(CI): 8.488-503.165] and those with solid breast mass compared with none had OR = 1.384 (95% CI: 1.022-1.873). Malignant tendency was strongly associated with increased risk of breast cancer, OR = 207.999(95%CI: 151.950-284.721). The risk of breast cancer increased with age, OR1 = 2.759 (95% CI: 1.837-4.144, 56-60 vs.40-45), OR2 = 2.047 (95% CI: 1.394-3.077, 51-55 vs. 40-45), OR3 = 1.668 (95% CI: 1.145-2.431). Normal resultsof B ultrasonic examination show a lower risk among participants, OR= 0.136 (95% CI: 0.085-0.218). Thosewomen with ductal papilloma compared with none were associated with breast cancer, OR=6.524 (95% CI:1.871-22.746). Therefore, this study suggests that clinical doctors should pay attention to these high-risk factors.