Lack of Association of Three Common Polymorphisms in Toll-like receptors (TLRs), TLR2+597T>C, +1350C>T and Arg753Gln with Cancer Risk: a Meta-analysis

Background: Single nucleotide polymorphisms (SNPs) occurring in Toll-like receptors (TLRs) may contributeto cancer risk. Many polymorphisms of TLR2 have been studied for associations, but the findings are conflicting.Methodology/Principal Findings: We performed a meta-analysis of 14 studies to confirm the association betweenTLR2+597T>C (rs3804099), +1350C>T (rs3804100) and Arg753Gln (rs5743708) polymorphisms and cancerrisk. Odds ratio (OR) and 95% confidence intervals (95% CI) were used to assess the strength of associations.There was no significant association between TLR2+597T>C and cancer risk in the codominant models (CCvs. TT: OR = 1.01, 95%CI = 0.86-1.17, Pheterogeneity = 0.148; CT vs. TT: OR = 0.92, 95%CI = 0.69-1.23, Pheterogeneity< 0.001), the recessive model (CC vs. CT+TT: OR = 0.86, 95%CI = 0.67-1.10, Pheterogeneity = 0.007) , the dominantmodel (CC+CT vs. TT: OR = 0.93, 95%CI = 0.76-1.15, Pheterogeneity = 0.001) and the allele model (C vs. T: OR =0.93, 95%CI = 0.81-1.08, Pheterogeneity = 0.019). Similarly, no significant associations between TLR2+1350C>T,Arg753Gln polymorphisms and cancer risk were found. However, in the sub-group analysis of ethnicities, thetrend of pooled ORs in Asians was opposite to Caucasians.
Conclusions: The present meta-analysis suggeststhat TLR2+597T>C (rs3804099), +1350C>T (rs3804100) and Arg753Gln (rs5743708) polymorphisms are notassociated with cancer risk.