Association Between Genetic Polymorphism of XRCC1 Gene and Risk of Glioma in а Chinese Population


Background: Gliomas are the most common type of primary brain tumor in adults, and the X-ray repaircomplementing group 1 gene (XRCC1) is an important candidate gene influencing its risk. The objective of thisstudy was to detect the influence of XRCC1 genetic polymorphisms on glioma risk. Materials and
Methods: Atotal of 629 glioma patients and 641 cancer-free subjects were enrolled in this case-control study. The genotypesof the c.1471G>A genetic polymorphism were determined by created restriction site-polymerase chain reaction(CRS-PCR) and DNA sequencing methods. The influence of the XRCC1 genetic polymorphism on glioma riskwas evaluated by association analysis.
Results: Our data indicated that the alleles/genotype of this genetic variantwas statistically associated with glioma risk. The AA genotype was statistically associated with the increased riskof glioma compared to the GG wild genotype (odds ratios (OR) = 1.89, 95% CI 1.25-2.87, P = 0.003). The allele-Amay contribute to increased the susceptibility to glioma (OR = 1.23, 95% CI 1.04-1.46, P = 0.017).
Conclusions:These preliminary findings indicate that the c.1471G>A genetic polymorphism of XRCC1 has the potential toinfluence glioma susceptibility, and might be used as molecular marker for assessing glioma risk.