Pin1 Promoter rs2233678 and rs2233679 Polymorphisms in Cancer: A Meta-analysis

PIN1 is one member of the parvulin PPIase family. By controlling Pro-directed phosphorylation, PIN1 playsan important role in cell transformation and oncogenesis. There are many polymorphisms in the PIN1 gene,including rs2233678 and rs2233679 affecting the PIN1 promoter. Recently, a number of case-control studies wereconducted to investigate the association between PIN1 gene rs2233678 and rs2233679 polymorphism and cancerrisk. However, published data are still conflicting. In this paper, we summarized data for 5,427 cancer cases and5,469 controls from 9 studies and attempted to assess the susceptibility of PIN1 gene polymorphism to cancersby a synthetic meta-analysis. Odds ratios (ORs) with 95% confidence intervals (CIs) were estimated to assess therelationship. All analyses were performed using Stata software. Our results suggested that rs2233678 representeda protective factor in overall analysis (CC vs GG: OR= 0.697, 95%CI: 0.498-0.976; CG vs GG: OR=0.701,95%CI: 0.572-0.858; Dominant model: OR= 0.707, 95%CI: 0.590-0.847; C allele vs G allele: OR=0.734, 95%CI:0.623-0.867) and especially for squamous cell carcinoma of the head and neck, lung cancer and breast cancer inAsians and Caucasians. The rs2233679 polymorphism was significantly associated with decreased cancer risk inoverall analysis (CT vs CC: OR=0.893, 95%CI=0.812-0.981; Dominant model: OR=0.893, 95%CI=0.816-0.976;T allele vs C allele; OR=0.947, 95%CI=0.896-1.000) and especially in Asians. In conclusion, our meta-analysissuggested that -842G>C (rs2233678) and -667C>T (rs2233679) may contribute to genetic susceptibility forcancer risks. Further prospective research with larger numbers of worldwide participants is warranted to drawcomprehensive and firm conclusions.