Impact of PSA and DRE on Histologic Findings at Prostate Biopsy in Turkish Men Over 75 Years of Age

Prostate specidic antigen (PSA) and digital rectal examination (DRE) are the known predictive factors forpositive prostate biopsies differing according to the age, region and race. There have been only very limitedstudies about the impact of PSA on histological findings at prostate biopsy in Turkey. The aim of this study was toevaluate the impact of PSA and clinical stage on histologic findings of prostate biopsy in men older than 75 yearsof age as a first study in the Turkish population. A total of 1,645 consecutive prostate biopsies were included, with194 men aged 75 or older. Cancer was identified in 104 patients (53.6%). Of the 104 positive biopsies, Gleasonscores were less than 7 in 53 (49%) patients, 7 or greater in 51 (51%) patients. Positive prostate biopsies weresignificantly correlated with advanced age (p=0.0001), abnormal DRE (p=0.0001) and raised PSA (p=0.0001).The prostate volume was significantly correlated with advanced age especially in prostate cancer patients over 75years, compared with those under 75 (p=0.0001). These results are useful for counseling men older than 75 yearsfor prostate cancer detection. However, PCa screening decisions are currently based on urologist judgment anddetection of latent asymptomatic disease is an important concern regarding costs, overdiagnosis, overtreatmentand quality of life (QOL) for men aged 75 years and older. Healthy old patients with a long life expectancy needto be carefully evaluated for eligibility for PCa screening.