Objective: To investigate whether the expression level of valosin-containing protein (VCP) is correlated withthe prognosis of primary orbital mucosa-associated lymphoid tissue (MALT) lymphoma. Methods: VCP expressionin 58 samples from primary orbital MALT lymphoma patients was determined by immunohistochemisty usingmonoclonal antibodies. Correlations between VCP expression level and prognosis were clarified by statisticalanalysis. Results: It was found that the percentage of VCP positive cells in samples of primary orbital MALTlymphoma ranged from 32% to 95%. The samples were divided into two groups (level 1 and level 2) accordingto the median value (45%) of the percentage of VCP positive cells. It was found that the expression level of VCPwas significantly correlated with recurrence (P=0.003) and tumor size (P=0.008). At the same time, the 5-yeardisease-free and overall survival rate of patients of level 1 was significantly better than that of level 2 (P=0.001;P=0.032). There was no observed correlation between the expression level of VCP and other clinical features. Conclusion: VCP could be a useful marker for predicting the prognosis of primary orbital MALT lymphoma.
(2013). Expression Level of Valosin Containing Protein is Associated with Prognosis of Primary Orbital MALT Lymphoma. Asian Pacific Journal of Cancer Prevention, 14(11), 6439-6443.
MLA
. "Expression Level of Valosin Containing Protein is Associated with Prognosis of Primary Orbital MALT Lymphoma". Asian Pacific Journal of Cancer Prevention, 14, 11, 2013, 6439-6443.
HARVARD
(2013). 'Expression Level of Valosin Containing Protein is Associated with Prognosis of Primary Orbital MALT Lymphoma', Asian Pacific Journal of Cancer Prevention, 14(11), pp. 6439-6443.
VANCOUVER
Expression Level of Valosin Containing Protein is Associated with Prognosis of Primary Orbital MALT Lymphoma. Asian Pacific Journal of Cancer Prevention, 2013; 14(11): 6439-6443.