Evaluation of Prognostic Factors and Survival Results in Pancreatic Carcinomas in Turkey

Background: The goal of this retrospective study was to evaluate patient characteristics, treatment modalitiesand prognostic factors in Turkish patients with pancreatic cancer. Materials and
Methods: Between January 1997and December 2012, 64 patients who presented to the Department of Radiation Oncology, Karadeniz TechnicalUniversity, Faculty of Medicine with a diagnosis of pancreatic cancer were evaluated. The E/K ratio of the caseswas 2.4/1 and the median age was 59.6 (32-80) years, respectively. Some 11 cases (18%) were stage 1, 21 (34.4%)were stage 2, 10 (16.4%) were stage 3, and 19 (31.1%) were metastatic.
Results: The mean follow-up time was15.7 months (0.7-117.5) and loco-regional recurrence was noted in 11 (40.7%) who underwent surgery whilemetastases were observed in 41 patients (66.1%). The median overall survival (OS) was 11.2 months and the 1,3 and 5-year OS rates were 41.7%, 9.9% and 7.9% respectively. The median disease-free survival (DFS) was 5.2month and the1, 2 and 5 year DFS were 22.6%, 7.6% and 3.8% respectively. On univariate analysis, prognosticfactors affecting OS included status of the operation (p<0.001), tumor stage (p=0.008), ECOG performance status(p=0.005) and CEA level (p=0.017).On multivariate analysis, prognostic factors affecting survival included statusof the operation (p=0.033) and age (p= 0.023).
Conclusions: In the current study, age and operation status wereindependent prognostic factors for overall survival with pancreatic patients. Thus, the patients early diagnosisand treatment ars essential. However, prospective studies with more patients are needed for confirmation.