Expression of Nuclear Factor Kappa B (NF-κB) as a Predictor of Poor Pathologic Response to Chemotherapy in Patients with Locally Advanced Breast Cancer


Background: NF-κB inhibits apoptosis through induction of antiapoptotic proteins and suppression ofproapoptotic genes. Various chemotherapy agents induce NF-κB translocation and target gene activation. Weconducted the present study to assess the predictive value of NF-κB regarding pathologic responses after receivingneoadjuvant chemotherapy. Materials and
Methods: We enrolled 131 patients with locally advanced invasiveductal breast carcinoma. Immunohistochemistry (IHC) was used to detect NF-κB expression. Evaluation ofpathologic response was elaborated with the Ribero classification.
Results: Expression of NF-κB was significantlyassociated with poor pathological response (p=0.02). From the multivariate analysis, it was found that the positiveexpression of NF-κB yielded RR=1.74 (95%CI 0.77 to 3.94).
Conclusions: NF-κB can be used as a predictor ofpoor pathological response after neoadjuvant chemotherapy.