Background: NF-κB inhibits apoptosis through induction of antiapoptotic proteins and suppression ofproapoptotic genes. Various chemotherapy agents induce NF-κB translocation and target gene activation. Weconducted the present study to assess the predictive value of NF-κB regarding pathologic responses after receivingneoadjuvant chemotherapy. Materials and Methods: We enrolled 131 patients with locally advanced invasiveductal breast carcinoma. Immunohistochemistry (IHC) was used to detect NF-κB expression. Evaluation ofpathologic response was elaborated with the Ribero classification. Results: Expression of NF-κB was significantlyassociated with poor pathological response (p=0.02). From the multivariate analysis, it was found that the positiveexpression of NF-κB yielded RR=1.74 (95%CI 0.77 to 3.94). Conclusions: NF-κB can be used as a predictor ofpoor pathological response after neoadjuvant chemotherapy.
(2014). Expression of Nuclear Factor Kappa B (NF-κB) as a Predictor of Poor Pathologic Response to Chemotherapy in Patients with Locally Advanced Breast Cancer. Asian Pacific Journal of Cancer Prevention, 15(2), 595-598.
MLA
. "Expression of Nuclear Factor Kappa B (NF-κB) as a Predictor of Poor Pathologic Response to Chemotherapy in Patients with Locally Advanced Breast Cancer". Asian Pacific Journal of Cancer Prevention, 15, 2, 2014, 595-598.
HARVARD
(2014). 'Expression of Nuclear Factor Kappa B (NF-κB) as a Predictor of Poor Pathologic Response to Chemotherapy in Patients with Locally Advanced Breast Cancer', Asian Pacific Journal of Cancer Prevention, 15(2), pp. 595-598.
VANCOUVER
Expression of Nuclear Factor Kappa B (NF-κB) as a Predictor of Poor Pathologic Response to Chemotherapy in Patients with Locally Advanced Breast Cancer. Asian Pacific Journal of Cancer Prevention, 2014; 15(2): 595-598.
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